Associate Professor Kiropoulos works at the nexus of research, clinical practice and clinical teaching. Her research interests include mood and anxiety disorders, transdiagnostic mechanisms involved in the development and maintenance of mood, anxiety and eating disorders and the development and evaluation of face-to-face and e-mental health psychological interventions for depression and anxiety disorders in various clinical and medically ill populations (such as multiple sclerosis). 

She has previously held a research and clinical leadership role within the Psychology Department, Royal Melbourne Hospital as part of a joint research and teaching position between the Melbourne School of Psychological Science, University of Melbourne and the Psychology Department, Royal Melbourne Hospital. She was the inaugural Clinic Director, University of Melbourne Psychology Clinic.

Associate Professor Kiropoulos currently heads the Mood and Anxiety Disorders Lab and co-ordinates a number of subjects in the Master of Clinical Psychology in the Melbourne School of Psychological Sciences. She also heads the newly developed Clinical Psychology Service in the Neuroimmunology Centre (NIC) at the Royal Melbourne Hospital.

Associate Professor Kiropoulos has developed a number of short courses for health professionals in the areas of compassion fatigue, cross-cultural clinical practice and managing depression and anxiety in chronic illness.